Endocrine Abstracts

Background: There is growing evidence supporting TNF-related apoptosis-inducing ligand (TRAIL) involvement in weight and body composition regulation, which are classically influenced by thyroid hormones. This study aimed at investigating the relationship between thyroid hormones and TRAIL.Methods: Circulating TRAIL was measured in 40 controls, 40 hyperthyroid, and 25 hypothyroid patients before and after their respective treatments. In the same patients ...

Introduction: Experimental studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) has the potential to treat type 2 diabetes mellitus (T2DM). We have recently demonstrated that TRAIL delivery ameliorates T2DM in the high-fat diet-fed mouse. This study aimed at evaluating whether TRAIL had the potential to treat not only T2DM but also diabetic nephropathy.Methods/design: Based on this background, 15 male db/H mice ...

Introduction: Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) may have an important role in the treatment of type 2 diabetes mellitus (T2DM). It has been shown that TRAIL deficiency worsens T2DM and that TRAIL delivery, when it is given before disease onset, slows down T2DM development. This study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat T2DM.Methods/...